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KMID : 1037220160220030129
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Archives of Aesthetic Plastic Surgery
2016 Volume.22 No. 3 p.129 ~ p.134
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The Effects of Vascular Endothelial Growth Factor on Capsule Formation around Silicone Implant in Rats
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Kim Da-Han
Song You-Seong
Song Seung-Yong
Kim Chung-Hun
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Abstract
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Background : The purpose of this study was to examine the effects of a single administration of vascular endothelial growth factor (VEGF) in promoting the angiogenesis and thereby reducing the formation of capsular contracture.
Methods : We treated 24 female Sprague-Dawley rats with (1) 5 mM Tris Buffer and 150 mM NaCl 0.1 cc, (2) VEGF 15 μg/0.1 cc, (3) VEGF 150 μg/0.1 cc during placement of the implant, or (4) VEGF 150 μg/0.1 cc and VEGF 300 μg/0.2 cc. We histopathologically measured the thickness of the capsule and the number of blood vessels.
Results : All experimental groups had a significant difference in the thickness of the capsule compared to the control group (P<0.001). There was no significant difference between experimental group 2 and experimental group 3. The number of blood vessels formed around the capsule was significantly greater in all the experimental groups compared with the control group (P<0.05). There was no significant difference between the experimental groups. There was a significant negative correlation between the thickness of the capsule and the number of blood vessels (Spearman's correlation coefficient, 0.2732; P<0.0001).
Conclusions :A single administration of VEGF reduced formation of the capsule and increased the vascularity around the implant, supporting the hypothesis that prevention of tissue ischemia can be a treatment strategy for capsular contracture.
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KEYWORD
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Breast implants, Contracture, Rats, Vascular endothelial growth factor
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